Differential Analysis Tool
Differential Analysis Tool uses a probabilistic framework to build a
differential network based on metabolomic data. The differential correlation (i.e., change in the
correlation between two metabolites within one biological group versus their correlation within
biological group) is used to build a network. In addition, the change in the level of each
between the two biological groups is calculated by statistical methods. The differential network
the statistical significance levels are combined to calculate a network activity score for each
metabolite to select disease-associated metabolites.